Estudio Químico-Farmacéutico del ingrediente activo UC-244
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Fecha
2009-06-25
Autores
Echevarría Valdés, Yoslainy
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Editor
Universidad Central "Marta Abreu" de las Villas
Resumen
El 2-(2-metil-2-nitrovinil)-furano, conocido por UC-244, es una sustancia sintetizada en el Centro de Bioactivos Químicos de la Universidad Central de Las Villas, que presenta propiedades bioactivas como bactericida y fungicida, cuya acción ha sido estudiada por otros investigadores (Rodríguez R., 1994; Salazar E., 1996 y Saucedo, 2004;). Su tecnología de producción ha sido mejorada y actualmente se trabaja en el estudio del producto obtenido en las nuevas condiciones, a fin de realizar los estudios químico-farmacéuticos, determinando algunos parámetros de calidad, entre ellos la temperatura de fusión, el contenido de impurezas de metales pesados, pérdidas por desecación y cenizas. Se evalúan algunos parámetros de validación de las técnicas analíticas para su cuantificación por cromatografía de capa delgada combinada con espectrofotometría UV y cromatografía de gases con detectores de ionización por llama y espectrometría de masa. Se demuestra que las técnicas estudiadas son lineales, precisas y exactas, refiriéndose los valores obtenidos para los parámetros de validación. Se comprueba que no existen diferencias significativas en los resultados obtenidos por las técnicas cromatográficas gaseosas.
The 2-(2-metil-2-nitrovinil)-furan, known by UC-244, it is a substance synthesized in the Bioactive Chemical Center at Central University of Las Villas. The compound present bioactive properties like germicide and fungicide whose action has been established by other investigators (Rodriguez R., 1994; Salazar E., 1996 and Saucedo, 2004.). Their production technology has been improved and at present we works on the study of the product properties obtained under the new conditions, in order to carry out the chemical-pharmacists studies, determining some parameters of quality, among them the melting point temperature, content of impurities of heavy metals, losses for drying and totals ash. Some parameters of validation of the analytic techniques were evaluated by quantification with thin layer chromatography combined with ultraviolet spectrometry and also employing gas chromatography of gases with ionization and mass detector. In our paper has been demonstrated that the studied techniques are linearly, precise and accurate, referring the values obtained for the validation parameters. Analytics results obtained demonstrated that don't exist significant differences in the results by gaseous chromatographic methods employed.
The 2-(2-metil-2-nitrovinil)-furan, known by UC-244, it is a substance synthesized in the Bioactive Chemical Center at Central University of Las Villas. The compound present bioactive properties like germicide and fungicide whose action has been established by other investigators (Rodriguez R., 1994; Salazar E., 1996 and Saucedo, 2004.). Their production technology has been improved and at present we works on the study of the product properties obtained under the new conditions, in order to carry out the chemical-pharmacists studies, determining some parameters of quality, among them the melting point temperature, content of impurities of heavy metals, losses for drying and totals ash. Some parameters of validation of the analytic techniques were evaluated by quantification with thin layer chromatography combined with ultraviolet spectrometry and also employing gas chromatography of gases with ionization and mass detector. In our paper has been demonstrated that the studied techniques are linearly, precise and accurate, referring the values obtained for the validation parameters. Analytics results obtained demonstrated that don't exist significant differences in the results by gaseous chromatographic methods employed.
Descripción
Palabras clave
2-(2-metil-2-nitrovinil)-furano, Cromatografía de Gases, Chromatography, Gas, Cromatografía de Capa Delgada, Chemical-Pharmacist Parameters, Thin Layer Chromatography, Validation