Desarrollo de formulaciones de tabletas a partir de las hojas de Boldoa purpurascens Cav. Evaluación preliminar
Fecha
2017
Autores
Salgado León, Lorraine
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Editor
Universidad Central “Marta Abreu” de Las Villas. Facultad de Química Farmacia. Departamento de Farmacia
Resumen
En países como Cuba el empleo terapéutico de las plantas en la medicina tradicional constituye una parte importante de la cultura. El género Boldoa ha merecido la atención de varios investigadores que buscan correlacionar diversas acciones farmacológicas atribuidas al género y los constituyentes químicos encontrados en algunos de las especies, especialmente los fitofenoles(1). Boldoa purpurascens Cav, es tal vez una de las especies menos conocidas dentro del género y la familia Nyctaginaceae; sin embargo, en Cuba y otras regiones de América crece de forma silvestre en jardines y parques y se emplea tradicionalmente como un potente diurético. En este trabajo se pretendió elaborar tabletas a partir de los sólidos pulverulentos obtenidos de las hojas de esta planta. Se determinaron las propiedades reológicas de los sólidos pulverulentos de las hojas de Boldoa purpurascens Cav de tamaño de partícula 1 y 2 mm. Se diseñaron cuatro formulaciones, empleando 50 mg como dosis del principio activo, dos de ellas se realizaron empleando el método de compresión directa y otras dos utilizando el método de granulación húmeda, incorporando PVP como agente aglutinante. Finalmente se evaluó la calidad de las tabletas diseñadas. Se concluyó que las propiedades de flujo de los polvos evaluados resultaron deficientes; las formulaciones obtenidas por el método de granulación húmeda resultaron superiores en calidad a las formulaciones obtenidas por compresión directa. La formulación IV demostró ser la de mejores propiedades físico-técnicas y tecnológicas, es por esto que se selecciona como la más adecuada para continuar con el desarrollo del producto
In countries like Cuba the therapeutic use of plants in traditional medicine constitutes an important part of the culture. The Boldoa genus has attracted the attention of several researchers who seek to correlate different pharmacological actions attributed to the genus and chemical constituents found in some of the species, especially phytophenols. Boldoa purpurascens Cav, is perhaps one of the lesser known species within the genus and the family Nyctaginaceae; However, in Cuba and other regions of America it grows wild in gardens and parks and is traditionally used as a potent diuretic. In this work it was tried to elaborate tablets from the pulverulent solids obtained from the leaves of this plant. The rheological properties of the powdery solids of the leaves of Boldoa purpurascens Cav of particle size 1 and 2 mm were determined. Four formulations were designed, using 50 mg as dosage of the active principle, two of them were made using the method of direct compression and two others using the method of wet granulation, incorporating PVP as binding agent. Finally, the quality of the tablets was evaluated. It was concluded that the flow properties of the powders evaluated were deficient; The formulations obtained by the wet granulation method were superior in quality to the formulations obtained by direct compression. Formulation IV proved to be the one with the best physical-technical and technological properties, which is why it is selected as the most suitable to continue the development of the product.
In countries like Cuba the therapeutic use of plants in traditional medicine constitutes an important part of the culture. The Boldoa genus has attracted the attention of several researchers who seek to correlate different pharmacological actions attributed to the genus and chemical constituents found in some of the species, especially phytophenols. Boldoa purpurascens Cav, is perhaps one of the lesser known species within the genus and the family Nyctaginaceae; However, in Cuba and other regions of America it grows wild in gardens and parks and is traditionally used as a potent diuretic. In this work it was tried to elaborate tablets from the pulverulent solids obtained from the leaves of this plant. The rheological properties of the powdery solids of the leaves of Boldoa purpurascens Cav of particle size 1 and 2 mm were determined. Four formulations were designed, using 50 mg as dosage of the active principle, two of them were made using the method of direct compression and two others using the method of wet granulation, incorporating PVP as binding agent. Finally, the quality of the tablets was evaluated. It was concluded that the flow properties of the powders evaluated were deficient; The formulations obtained by the wet granulation method were superior in quality to the formulations obtained by direct compression. Formulation IV proved to be the one with the best physical-technical and technological properties, which is why it is selected as the most suitable to continue the development of the product.
Descripción
Palabras clave
Plantas Medicinales, Medicina Tradicional, Boldoa purpurascens Cav.